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Liquid Carbon - Murphy's #1 in industry.
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Liquid Carbon
Date: 2009-03-12 20:40
Subject: Murphy's #1 in industry.
Security: Public
Tags:crystals, industry
  In particular, the unexpected appearance in early 1998 of a more thermodynamically stable form (Form II) of ritonavir (Norvir, Abbott Laboratories, protease inhibitor for the treatment of HIV), with different dissolution properties compared to those of the earlier commercial Form I. Form II is <50% as soluble as Form I, resulting in the observed poor dissolution behavior and eventual withdrawal of the capsule from the market. This incident had serious implications for the marketed product and the patients receiving the drug. The project was suspended until a modified procedure was found. Renitidin, sertraline, and frentizole are some important examples of pharmaceuticals that exhibit polymorphism.
  This is from this OPRD ASAP; they were dealing with a similar issue. They have ultimately performed some 3600 recrystallization before they found the right one.
  Reminds me how easy my life is and how badly I suck at recrystallizations.
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chaostheory
User: chaostheory635
Date: 2009-03-13 03:58 (UTC)
Subject: (no subject)
i <3 recrystallization :)
i do wish i understood xtal polymorphism & growth in general a lot better, though
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Liquid Carbon
User: liquidcarbon
Date: 2009-03-13 04:11 (UTC)
Subject: (no subject)
Meh. I only love crystals. But I'm too impatient to get those.
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chaostheory
User: chaostheory635
Date: 2009-03-13 04:15 (UTC)
Subject: (no subject)
just hide it in a drawer and forget about it, man. after enough time, even the cruddiest goo usually gives something shiny...
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Liquid Carbon
User: liquidcarbon
Date: 2009-03-13 04:19 (UTC)
Subject: (no subject)
Oh yeah, I've got beautiful green crystals from brown-violet (!) crap over the winter break.
I haven't come to the hood in quite some time anyway =\
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chaostheory
User: chaostheory635
Date: 2009-03-13 05:00 (UTC)
Subject: (no subject)
awwwwww :( too busy with classes?
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Liquid Carbon
User: liquidcarbon
Date: 2009-03-13 05:08 (UTC)
Subject: (no subject)
That, too. Plus, I volonteered to go to ACS meeting in SLC back in October. I regret it now. Tried to back off, but it was too late.
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