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Liquid Carbon - Digging Chemdraw.
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Liquid Carbon
Date: 2009-06-26 03:40
Subject: Digging Chemdraw.
Security: Public
Tags:advice, drawing, making molecules, total synthesis
  Folks, we're about to reach the highest Dan of Chemdraw, the mastery of which enables you to make molecules without even lifting your ass from the chair. Yeah, dream on.

  Last time I was talking about some basics, and also hotkeys, which are absolutely crucial to productivity in any computer work. Quoting myself, "what ChemDraw really lacks is the hotkeys for switching between different drawing tools" — now I refute this statement. Find a file called CS Chemdraw HotKeys.txt under ChemDraw Items folder. On XP it's hiding somewhere in the Application Data dumpster, I hope you can find in on a Mac (yeah, I'm a PC, whatever). You can manually edit the hotkeys in there. Here's how I have it set up:

1 TOOL_MARQUEE
! TOOL_LASSO
2 TOOL_SOLIDBOND
@ TOOL_ACYCLICCHAIN
3 TOOL_TEXT
4 TOOL_ARROW
$ TOOL_CYCLOBUTANE
5 TOOL_CYCLOPENTANE
% TOOL_CYCLOPROPANE
6 TOOL_CYCLOHEXANE
^ TOOL_BENZENE
  It's a little funny that these settings sit in a separate .txt file, but this is what we get when we don't provide much needed feedback to the developers. I'm going to write them. Some of them (arrows, brackets) actually don't work.

  Finally, I present you... the "making" of the notorious aspidophytine. *exasperated gasp* However, let us not be overly cynical, for The Man actually gave us ChemDraw. I learned it from the preface to "The Logic of Chemical Synthesis". Moreover, in all his publications EJ actually abides by his original style used in the book, which quite different from what's commonly used. You can read about a recent synthesis of aspidophytine here at TotSyn.com. And, seriously, Angewandte, you waved the haplophytine flag like a year ago already, and it's still "almost published" in the VIP papers. Haplophytine is the bigger cousin of aspidophytine, which might have killed many more Japanese grad students. We just don't know about it, because they go straight to heaven North Korea.

  Note how my cursor doesn't even leave the screen to reach for different drawing tools. Note the use of Rotate and Join tools. This was the fifth try, I believe. This is at native speed, try beating my 71 seconds!



  Recorded with the outrageously awesome and free CamStudio. Drawn at 200% magnification. Drawing settings used:
Fixed Length: 0.525 cm
Bold Width: 0.07 cm
Line Width: 0.035 cm
Margin Width: 0.07 cm
Hash Spacing: 0.084 cm
Font: Calibri, size 9
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User: (Anonymous)
Date: 2009-06-26 20:47 (UTC)
Subject: (no subject)
I work for CambridgeSoft and I appreciate your site and the video you posted. However, watching you draw the molecule I see ways you could have inproved your speed significantly. One example was when you wanted to fuse the cyclopentane ring to the 2 fused cyclohexane rings, all you had to do was switch to the cyclopentane tool and click on one of the fused atoms. The ring would automatically join when you wanted it. Another example, the first cyclopentane ring can be rotated intot he position you want just by holding down the left mouse button and dragging until the ring is in the orientation you like.
But I still like the movie.
Jerry
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Liquid Carbon
User: liquidcarbon
Date: 2009-06-27 23:13 (UTC)
Subject: (no subject)
Hi, Jerry! It's very surprising and nice to hear from you - and so fast!

example 1 - indeed, in 15 degree increments and with a steady hand I could draw this first cyclopentane. For some reason, I got used to rotate cyclopentanes manually.

example 2 - nope. It works if you want to fuse in a cyclohexane, cyclopentane ends up attached only to the bond, giving [4.4.3]-propellane. It doesn't work either if you try to fuse the third ring to a 5,6-bicycle.

Would you mind sharing your contact with me so that I could message you directly on another matter? My e-mail is liquidc % gmail
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User: (Anonymous)
Date: 2009-07-03 15:36 (UTC)
Subject: Additional short cuts
Chemdraw also has short cuts for bonds and atoms that you can customize. For example I noticed that you typed in OMe. What I do is designate Shift O for OMe that way I won't have to type it in. Lower case O gives me O. If you hover over bonds you can change them from hash (h) dash (d) bold (b), etc.. Below is my hot key list.

http://www.columbia.edu/~kt2155/CS%20ChemDraw%20HotKeys.txt
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Liquid Carbon
User: liquidcarbon
Date: 2009-07-06 06:32 (UTC)
Subject: Re: Additional short cuts
Nice, thanks!
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virgin-suicide
User: virgin_suicide0
Date: 2009-11-05 00:35 (UTC)
Subject: (no subject)
Holy Ghost! Holy Ghost!!!
I knew they were hiding smth from me!
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Liquid Carbon
User: liquidcarbon
Date: 2009-11-22 00:06 (UTC)
Subject: (no subject)
Life's a box of chocolates. :)
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